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A Technique for the Induction of Labor by the Extraovular Administration of Prostaglandin F2α
Author(s) -
Ishikawa Yoshitsugu,
Uneki Katsumi,
Fukui Hideki,
Futakawa Kiyoshi,
Ogawa Tatsuhiro
Publication year - 1976
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1976.tb00081.x
Subject(s) - medicine , saline , prostaglandin , childbirth , induction of labor , catheter , oxytocin , uterus , anesthesia , labor induction , obstetrics , pregnancy , surgery , biology , genetics
Ishikawa, Y., Uneki, K., Fukui, H., Futakawa, K. and Ogawa, T. (Dept. of Obstetrics and Gynecology, Kobe Red Cross Hospital, Kobe, Hyogo 650, Japan). A technique for the induction of labor by the extraovular administration of prostaglandin F2α . Int J Gynaecol Obstet 14 : 439–444, 1976. Prostaglandin F2α (PG F2α) was administered to pregnant women at a dosage of 50 μg or 100 μg by extraovular route around the expected time of childbirth in order to induce labor. (1) PG F2α 50 μg or 100 μg dissolved in 10ml of physiological saline solution was infused by extraovular administration through the cervical canal of the uterus with the use of Nelaton catheter No. 9. The catheter was then immediately withdrawn and the patient allowed to return home. (2) Instillation of 10ml of physiological saline solution was carried out for control purposes. (3) Those who reported labor contractions within 24 hours after the infusion were regarded as cases of excellent response, and those who reported labor contractions more than 24 hours after the infusion, or those who showed dilatation and improvement in effacement of the uterine cervical canal though without the occurrence of labor contractions were deemed to be cases of good response. The overall positive response rate (excellent plus good) was 78.9% for Primiparae and 85.7% for multiparae in the group receiving 50 μg and 89.5% for primiparae and 100% for multiparae in the group receiving 100 μg. (4) Labor contractions were induced at a rate of almost 100% in those who showed dilatation of the cervical canal of the uterus to the extent of 3 cm or more and effacement to the extent of 50% or more. (5) It is advisable to perform reinfusion of PG F2α or instillation of PG F2α as a post‐treatment in patients with good responses. (6) The infusion of PG F2α is effective for the induction of labor in older Primiparae, cases of breech presentation and suspected cases of CPD. (7) There were some cases of enhanced response when PG F2αwas given as posttreatment.