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Two Cases of Clarithromycin‐Induced Digoxin Toxicity
Author(s) -
Guerriero Stephanie E.,
Ehrenpreis Eli,
Gallagher Kathryn L.
Publication year - 1997
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1997.tb03796.x
Subject(s) - digoxin , clarithromycin , toxicity , medicine , pharmacology , concomitant , therapeutic index , drug interaction , drug , heart failure , helicobacter pylori
Two patients experienced clarithromycin‐induced digoxin toxicity. Both had stable renal function within normal limits and had been maintained on a consistent dosage of digoxin. No changes in drug therapy had been made except for the addition of clarithromycin. Administration of clarithromycin to patients receiving long‐term digoxin therapy may induce digoxin toxicity. When concomitant therapy is employed, patients should be closely monitored for clinical signs and symptoms of digoxin toxicity, and digoxin concentrations should be measured to avoid it.