Premium
Pharmacokinetics of Fluconazole in Serum and Cerebrospinal Fluid in a Patient with AIDS and Cryptococcal Meningitis
Author(s) -
Chin Tom,
Fong I. W.,
Vandenbroucke A.
Publication year - 1990
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1990.tb02588.x
Subject(s) - fluconazole , cryptococcal meningitis , cerebrospinal fluid , pharmacokinetics , medicine , meningitis , viral meningitis , cryptococcosis , antifungal , human immunodeficiency virus (hiv) , virology , immunology , bacterial meningitis , dermatology , viral disease , pediatrics
The detailed pharmacokinetics of fluconazole in serum and cerebrospinal fluid (CSF) were studied in a patient with acquired immunodeficiency syndrome and cryptococcal meningitis, after an intravenous dose of 400 mg. Fluconazole exhibited a serum elimination half‐life of 34.2 hours, distribution volume of 0.56 17kg, and clearance of 0.19 ml/min/kg. Peak CSF concentration occurred at 4 hours after the dose. Overall penetration of fluconazole based on the ratio of areas under the curve of CSF to serum was 70%. The drug exhibited an excellent pharmacokinetic profile for treatment of central nervous system fungal infections.