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Atorvastatin Does Not Alter the Anticoagulant Activity of Warfarin
Author(s) -
Stern Ralph,
Abel Robert,
Gibson Gordon L.,
Besserer Judith
Publication year - 1997
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1997.tb04288.x
Subject(s) - warfarin , atorvastatin , dosing , medicine , anticoagulant , prothrombin time , cyp2c9 , pharmacology , atrial fibrillation , metabolism , cytochrome p450
Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two‐week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustments in warfarin dosing should not be necessary.