Transcranial Doppler to Evaluate the Effects of Antihypertensive Medication on Cerebral Blood Flow Velocity | Zendy

Fagan Susan C. | Zendy; Bindlish Vinita | Zendy; Robert Sylvie | Zendy; Steigerwalt Susan P. | Zendy; Ramadan Nabih M. | Zendy

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Transcranial Doppler to Evaluate the Effects of Antihypertensive Medication on Cerebral Blood Flow Velocity

Author(s) -

Fagan Susan C.,

Bindlish Vinita,

Robert Sylvie,

Steigerwalt Susan P.,

Ramadan Nabih M.

Publication year - 1992

Publication title -

the journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.92

H-Index - 116

eISSN - 1552-4604

pISSN - 0091-2700

DOI - 10.1002/j.1552-4604.1992.tb03790.x

Subject(s) - nifedipine , middle cerebral artery , medicine , transcranial doppler , cerebral blood flow , blood pressure , blood flow , vasodilation , anesthesia , cerebral circulation , cardiology , cerebral arteries , hemodynamics , ischemia , calcium

The effect of oral nifedipine on cerebral blood flow velocity was studied in six elderly hypertensive patients using transcranial Doppler. Serial measurements of blood pressure (BP), middle cerebral artery (MCA) flow velocity and nifedipine serum concentrations were obtained over an 8‐hour period. The authors found a significant inverse relationship between MCA velocities and nifedipine concentrations, independent of BP changes. These results are consistent with a direct vasodilatory effect of nifedipine on cerebral vessels and support the use of TCD in pharmacodynamic investigations of the cerebral vasculature.

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