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Impaired Bioavailability of Famotidine Given Concurrently with a Potent Antacid
Author(s) -
Barzaghi N.,
Gatti G.,
Crema F.,
Perucca E.
Publication year - 1989
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1989.tb03399.x
Subject(s) - famotidine , antacid , bioavailability , ingestion , oral administration , pharmacology , chemistry , medicine
The effect of a high potency antacid on the oral bioavailability of a single dose of famotidine (40 mg) was evaluated in normal volunteers according to a randomized cross‐over design. Ingestion of the antacid concurrently with famotidine resulted in a significant reduction of peak plasma famotidine concentration (from 156 ± 22 to 104 ± 7 , P < 0.05) and area under the famotidine plasma concentration curve (from 956 ± 125 to 607 ± 56 , P < 0.02). No significant interaction was observed when the antacid was ingested 2 hours after famotidine administration .