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The Effects of Flurbiprofen, Aspirin, Cimetidine, and Antacids on the Gastric and Duodenal Mucosa of Normal Volunteers. An Endoscopic and Photographic Study
Author(s) -
Friedman H.,
Seckman C. E.,
Schwartz J. H.,
Lanza F. L.,
Royer G. L.,
Stubbs C. M.
Publication year - 1989
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1989.tb03382.x
Subject(s) - flurbiprofen , cimetidine , aspirin , medicine , irritation , duodenum , gastroenterology , stomach , drug , gastric mucosa , anesthesia , pharmacology , immunology
This 7‐day, single blind, randomized endoscopic tolerance study compared daily doses of 100, 150 and 200 mg flurbiprofen with 2600 mg aspirin. After seven days the flurbiprofen 100 and 150 mg groups had significantly less gastric irritation than the flurbiprofen 200 mg and aspirin groups. Flurbiprofen showed a linear dose‐response relationship with respect to gastric injury and serum drug levels. Four subjects each on aspirin and flurbiprofen with the most severe injuries continued on their medications plus cimetidine and antacids for four more weeks. Both drug groups showed clinical improvement in the gastroduodenal area. In conclusion, flurbiprofen and aspirin therapy can be tolerated in the presence of gastroduodenal irritation by concomitantly administering cimetidine and antacids.