Premium
Hemodynamic Effects of Labetalol in Young and Older Adult Hypertensives
Author(s) -
Buell James C.,
Eliot Robert S.,
Plachetka John R.,
Little Mark R.
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb03153.x
Subject(s) - labetalol , blood pressure , medicine , placebo , hemodynamics , heart rate , anesthesia , cardiac index , stroke volume , vascular resistance , diastole , cardiac output , cardiology , alternative medicine , pathology
Twenty young (45 years or younger) and 20 older (55 years or older) adult patients with mild hypertension were enrolled in this study to compare the hemodynamic effects of labetalol versus placebo in two age groups. Ten patients in each group were randomly assigned to receive either a single oral dose of labetalol (200 mg) or placebo. Hemodynamic parameters were recorded immediately before and two hours after ingestion. Labetalol was more effective than placebo in significantly lowering systolic blood pressure (−11 versus + 5 mm Hg, −23 versus +4 mm Hg), diastolic blood pressure (−9 versus + 2 mm Hg, −12 versus +5 mm Hg), and total systemic resistance (−259 versus +42 dynes‐sec cm −5 , −390 versus + 74 dynes‐sec cm −5 ) in young and older hypertensive subjects, respectively. There was no signifcant changes in heart rate, stroke volume index, or cardiac index in either age group. These data indicate that labetalol lowers blood pressure in young an older hypertensives primarily by reducing peripheral resistance and that the antihypertensive effect may be somewhat greater in older patients.