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Phenytoin Pharmacokinetics in Therapeutic Plasmapheresis
Author(s) -
Nasca Thomas J.,
Huff Nancy,
Livengood Bruce H.
Publication year - 1985
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1985.tb02843.x
Subject(s) - plasmapheresis , phenytoin , pharmacokinetics , medicine , myasthenia gravis , therapeutic drug monitoring , anesthesia , albumin , therapeutic plasma exchange , pharmacology , gastroenterology , immunology , epilepsy , antibody , psychiatry
Total and free serum phenytoin concentrations and net phenytoin removal were examined in two stable patients (henceforth referred to as patient D.K. and patient C.L.) receiving therapeutic plasmapheresis for myasthenia gravis at Mercy Hospital. Similar serum determinations were obtained on the days prior to and after plasmapheresis in order to determine if a single patient plasma volume exchange replaced isovolumetrically with a 4.0 g% albumin solution would significantly alter serum concentrations of phenytoin.