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The Pharmacokinetics and Pharmacology of Oral Diltiazem in Normal Volunteers
Author(s) -
KINNEY EVLIN L.,
MOSKOWITZ RALPH M.,
ZELIS ROBERT
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb01778.x
Subject(s) - diltiazem , pharmacokinetics , medicine , dosing , angina , pharmacology , oral administration , blood pressure , clinical pharmacology , anesthesia , calcium , myocardial infarction
Oral diltiazem is being used increasingly in the treatment of Prinzmetal's angina. This study investigated the pharmacokinetics, electrocardiographic effects, and blood pressure response of normal male volunteers to various single oral doses of diltiazem. Doses selected were 30, 60, 90, and 120 mg. Thirteen subjects received 30 mg. 12 subjects received 60 mg, 10 subjects received 90 mg, diltiazem, and four subjects received 120 mg diltiazem AUCs for the 60, 90, and 120 mg doses were 565, 984, and 1258 ng/ml · hr, respectively. The values for t ½ , β, and t max were similar after each dosing.