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Plasma Protein Binding of d ‐Propoxyphene in Normal Subjects and Anephric Patients
Author(s) -
GIACOMINI KATHLEEN M.,
GIBSON THOMAS P.,
LEVY GERHARD
Publication year - 1978
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1978.tb02429.x
Subject(s) - propoxyphene , metabolite , plasma concentration , medicine , therapeutic plasma exchange , pharmacology , endocrinology , chemistry , analgesic
The free fraction of d-propoxyphene in the plasma of normal subjects is 0.24 +/- 0.02 (mean +/- S.D.) and is not concentration dependent in the usual therapeutic and toxic conentration range. Renal failure and relatively high concentrations of d-norpropoxyphene, the major metabolite of d-propoxyphene, have no significant effect on the plasma protein binding of d-propoxyphene.