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Astrocytes support incomplete differentiation of an oligodendrocyte precursor cell.
Author(s) -
Keilhauer G.,
Meier D.H.,
KuhlmannKrieg S.,
Nieke J.,
Schachner M.
Publication year - 1985
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1985.tb03962.x
Subject(s) - biology , oligodendrocyte , cellular differentiation , microbiology and biotechnology , precursor cell , cell , neuroscience , computational biology , genetics , gene , myelin , central nervous system
Glial fibrillary acidic protein‐positive astrocytes, but not neurons or fibroblasts, support the differentiation of an oligodendroglial precursor cell expressing O4 antigen and vimentin into an O4 antigen‐positive, but vimentin‐negative oligodendrocyte. Further maturation into galactocerebroside (O1)‐positive oligodendrocytes is, however, not achieved under the culture conditions used, neither in the presence of astrocytes nor neurons.