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Cholesteryl ester transfer protein: The controversial relation to atherosclerosis and emerging new biological roles
Author(s) -
Oliveira Helena C. F.,
de Faria Eliana C.
Publication year - 2011
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.448
Subject(s) - cholesterylester transfer protein , inflammation , phospholipid transfer protein , disease , lipoprotein , epidemiology , obesity , medicine , chemistry , biology , cholesterol , biochemistry , phospholipid , membrane
Cholesteryl ester transfer protein (CETP) exerts a profound impact on high‐density lipoprotein (HDL) metabolism and, consequently, on the risk of atherosclerosis development and cardiovascular mortality. Here, we review the complex relationship between CETP and atherosclerosis based upon the experimental, clinical, and epidemiological studies. In addition, we discuss the recent findings that expand the functions of CETP to new areas of interest such as Alzheimer's disease, inflammation, and obesity. © 2011 IUBMB IUBMB Life, 63(4): 272–276, 2011
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