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Selenium and selenoprotein function in brain disorders
Author(s) -
Pillai Roshan,
UyeharaLock Jane H.,
Bellinger Frederick P.
Publication year - 2014
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.1262
Subject(s) - selenoprotein , selenium , selenoprotein p , brain function , function (biology) , neuroscience , chemistry , computational biology , biology , microbiology and biotechnology , biochemistry , oxidative stress , glutathione peroxidase , catalase , organic chemistry
Abstract Selenoproteins are important for normal brain function, and decreased function of selenoproteins can lead to impaired cognitive function and neurological disorders. This review examines the possible roles of selenoproteins in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and epilepsy. Selenium deficiency is associated with cognitive decline, and selenoproteins may be helpful in preventing neurodegeneration in AD. PD is associated with impaired function of glutathione peroxidase selenoenzymes. In HD, selenium deters lipid peroxidation by increasing specific glutathione peroxidases. Selenium deficiency increases risk of seizures in epilepsy, whereas supplementation may help to alleviate seizures. Further studies on the mechanisms of selenoprotein function will increase our understanding of how selenium and selenoproteins can be used in treatment and prevention of brain disorders. © 2014 IUBMB Life, 66(4):229–239, 2014