Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition | Zendy

Tsilidis Konstantinos K. | Zendy; Allen Naomi E. | Zendy; Key Timothy J. | Zendy; SanJoaquin Miguel A. | Zendy; Bakken Kjersti | Zendy; Berrino Franco | Zendy; Fournier Agnès | Zendy; Lund Eiliv | Zendy; Overvad Kim | Zendy; Olsen Anja | Zendy; Tjønneland Anne | Zendy; Byrnes Graham | Zendy; Chajes Veronique | Zendy; Rinaldi Sabina | Zendy; BoutronRuault MarieChristine | Zendy; ClavelChapelon Francoise | Zendy; ChangClaude Jenny | Zendy; Kaaks Rudolf | Zendy; Bergmann Manuela | Zendy; Boeing Heiner | Zendy; Koumantaki Yvoni | Zendy; Palli Domenico | Zendy; Pala Valeria | Zendy; Panico Salvatore | Zendy; Tumino Rosario | Zendy; Vineis Paolo | Zendy; Bas BuenodeMesquita H. | Zendy; van Duijnhoven Fränzel J.B. | Zendy; van Gils Carla H. | Zendy; Peeters Petra H.M. | Zendy; Rodríguez Laudina | Zendy; González Carlos A. | Zendy; Sánchez MaríaJosé | Zendy; Chirlaque MariaDolores | Zendy; Barricarte Aurelio | Zendy; Dorronsoro Miren | Zendy; Khaw KayTee | Zendy; Rodwell Sheila A. | Zendy; Norat Teresa | Zendy; Romaguera Dora | Zendy; Riboli Elio | Zendy

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Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author(s) -

Tsilidis Konstantinos K.,

Allen Naomi E.,

Key Timothy J.,

SanJoaquin Miguel A.,

Bakken Kjersti,

Berrino Franco,

Fournier Agnès,

Lund Eiliv,

Overvad Kim,

Olsen Anja,

Tjønneland Anne,

Byrnes Graham,

Chajes Veronique,

Rinaldi Sabina,

BoutronRuault MarieChristine,

ClavelChapelon Francoise,

ChangClaude Jenny,

Kaaks Rudolf,

Bergmann Manuela,

Boeing Heiner,

Koumantaki Yvoni,

Palli Domenico,

Pala Valeria,

Panico Salvatore,

Tumino Rosario,

Vineis Paolo,

Bas BuenodeMesquita H.,

van Duijnhoven Fränzel J.B.,

van Gils Carla H.,

Peeters Petra H.M.,

Rodríguez Laudina,

González Carlos A.,

Sánchez MaríaJosé,

Chirlaque MariaDolores,

Barricarte Aurelio,

Dorronsoro Miren,

Khaw KayTee,

Rodwell Sheila A.,

Norat Teresa,

Romaguera Dora,

Riboli Elio

Publication year - 2010

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.25504

Subject(s) - colorectal cancer , medicine , cancer , oncology , prospective cohort study , hormone therapy , hormone replacement therapy (female to male) , european prospective investigation into cancer and nutrition , hormone , gynecology , breast cancer , testosterone (patch)

Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models stratified by center and age, and adjusted for body mass index, smoking, diabetes, physical activity and alcohol consumption. Compared to never use of HT at study enrolment, current use of estrogen‐only (HR, 1.02; 95% CI, 0.79–1.31) or estrogen plus progestin (HR, 0.94; 95% CI, 0.77–1.14) was not significantly associated with the risk of colorectal cancer, and these associations did not vary by recency, duration, route of administration, regimen or specific constituent of HT. Our results show no significant association of estrogen‐only or estrogen plus progestin therapy with colorectal cancer risk.

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