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Heilmittelchemische Studien in der heterocyclischen Reihe. 25. Mitteilung . Pyrazolo‐pyrimidine III Paraxanthin‐, Theobromin‐ und Theophyllin‐Analoga der Pyrazolo[3,4‐d]pyrimidin‐Reihe
Author(s) -
Schmidt P.,
Eichenberger K.,
Dreuey J.
Publication year - 1959
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19590420132
Subject(s) - theobromine , chemistry , theophylline , paraxanthine , caffeine , pyrimidine , stereochemistry , medicinal chemistry , organic chemistry , pharmacology , medicine , cyp1a2 , enzyme , endocrinology , cytochrome p450
The preparation of the paraxanthine, theobromine and theophylline isomers 1,5‐; 2,5‐ and 1,7‐; 2,7‐ and 5,7‐dimethyl‐4,6‐dioxo‐4,5,6,7‐tetrahydro‐pyrazolo[3,4‐d]‐pyrimidines is described and their structure established. A structurally specific synthesis of the caffeine and isocaffeine isomers 1,5,7‐ and 2,5,7‐trimethyl‐4,6‐ dioxo‐4,5,6,7‐tetrahydro‐pyrazolo [3,4‐d]pyrimidines has been realized.

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