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Potential therapeutic target and independent prognostic marker of TROP2 in laryngeal squamous cell carcinoma
Author(s) -
Wu Hao,
Xu Huiming,
Zhang Shu,
Wang Xudong,
Zhu Huijun,
Zhang Huilin,
Zhu Jin,
Huang Jianfei
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23138
Subject(s) - immunohistochemistry , medicine , lymph node , tissue microarray , pathology , head and neck squamous cell carcinoma , carcinoma , laryngeal neoplasm , metastasis , cancer , oncology , head and neck cancer , cancer research
Background The human trophoblastic cell surface antigen 2 (TROP2) gene is associated with the development of malignancies, but its expression in laryngeal squamous cell carcinoma (SCC) and its relationship with clinical characteristics of the disease remain undetermined. Methods Expression of TROP2 protein was detected by immunohistochemistry with a self‐made anti‐TROP2 antibody in laryngeal SCC tissue microarrays. Results Elevated expression of TROP2 was detected in laryngeal SCC tissues compared with adjacent noncancerous tissues. TROP2 expression in laryngeal SCC was related to tumor differentiation ( p = .0001) and lymph node metastasis ( p = .0352). Cox regression analyses confirmed that TROP2 expression ( p = .015), lymph node metastasis ( p = .001), degree of differentiation ( p = .002), tumor site ( p = .021), and T classification ( p = .003) were independent prognostic factors. Conclusions TROP2 can be used as an independent prognostic indicator for laryngeal SCC. © 2012 Wiley Periodicals, Inc. Head Neck 35: 1373–1378, 2013