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Liposarcoma of the head and neck: The University of Texas M. D. Anderson Cancer Center experience
Author(s) -
Davis Erica C.,
Ballo Matthew T.,
Luna Mario A.,
Patel Shreyakumar R.,
Roberts Dianna B.,
g Xiaolin,
Sturgis Erich M.
Publication year - 2009
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20923
Subject(s) - medicine , head and neck , head and neck cancer , retrospective cohort study , cancer , overall survival , oncology , liposarcoma , disease , surgery , pathology , sarcoma
Abstract Background. Our aim was to review our experience with liposarcoma of the head and neck region. Methods. This is a retrospective case series at a comprehensive cancer center (1945–2005). Results. Of 30 patients, 10 (33%) were initially misdiagnosed. Local recurrences were common (overall rate = 53%), and 4 patients (13%) developed distant metastases. Decreased crude disease‐specific survival rates were significantly associated with recurrence (especially distant recurrence [0%]), age less than 38 years (40%), and pleomorphic subtype (45%); however, in Kaplan‐Meier analyses, only larger tumor size, negative margins, round cell subtype, and pleomorphic subtype were associated with significantly decreased disease‐specific survival (log‐rank test p = .048, .041, .021, and .012, respectively). Conclusions. Based on this limited experience and existing literature, we continue to recommend surgery with negative margins as the treatment of choice and that adjuvant therapies should be considered in patients with high‐grade histology, large tumors, positive margins, or certain subsites. © 2008 Wiley Periodicals, Inc. Head Neck, 2009