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Postoperative intensity‐modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: Technique, early outcomes, and toxicity
Author(s) -
Hoppe Bradford S.,
Wolden Suzanne L.,
Zelefsky Michael J.,
Mechalakos James G.,
Shah Jatin P.,
Kraus Dennis H.,
Lee Nancy
Publication year - 2008
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.20800
Subject(s) - medicine , nasal cavity , paranasal sinuses , radiation therapy , lacrimal gland , cancer , nuclear medicine , sinus (botany) , surgery , pathology , botany , biology , genus
Abstract Background Our aim was to review Memorial Sloan‐Kettering Cancer Center's experience with postoperative intensity‐modulated radiotherapy (IMRT) for paranasal sinus, nasal cavity, and lacrimal gland cancer and report dosimetric measures, toxicity, and outcomes. Methods Between September 2000 and June 2006, 37 patients with paranasal sinus, nasal cavity, or lacrimal gland cancer underwent postoperative IMRT. Median values were as follows: prescription dose, 60 Gy (range, 50–70); PTV D95 , 99% (range, 79–101%); optic nerve Dmax, 53 Gy (range, 2–54); optic chiasm Dmax, 51Gy (range, 2–55). Acute and late toxicities were scored by Radiation Therapy Oncology Group morbidity criteria. Results Median follow‐up was 28 months. Two‐year local progression–free and overall survivals were 75% and 80%. No early‐ or late‐grade 3/4 radiation‐induced ophthalmologic toxicity occurred. Conclusions Preliminary results show that adjuvant IMRT in these patients is feasible, allowed for excellent planning target volume (PTV) coverage, and minimized dose delivered to optic structures. Longer follow‐up is warranted to assess the extent of late effects and outcomes. © 2008 Wiley Periodicals, Inc. Head Neck, 2008