Clonal structural chromosome aberrations in fibrous dysplasia | Zendy

Mertens Fredrik | Zendy; Albert Auxilium | Zendy; Heim Sverre | Zendy; Lindholm Johan | Zendy; Brosjö Otte | Zendy; Mitelman Felix | Zendy; Mandahl Nils | Zendy

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Clonal structural chromosome aberrations in fibrous dysplasia

Author(s) -

Mertens Fredrik,

Albert Auxilium,

Heim Sverre,

Lindholm Johan,

Brosjö Otte,

Mitelman Felix,

Mandahl Nils

Publication year - 1994

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870110411

Subject(s) - biology , somatic evolution in cancer , karyotype , somatic cell , dysplasia , chromosome , fibrous dysplasia , genetics , microbiology and biotechnology , anatomy , gene

Cytogenetic analysis of short‐term cultures from a case of monostotic fibrous dysplasia in a 14‐year‐old girl revealed multiple clonal structural rearrangements with evidence of clonal evolution. The karyotype was 46,XX,del(3)(q27),add(10)(q22), add(12)(p13)/46,idem,t(3;8)(p21;q13),add(10)(q26),der(15)del(15)(q15q22)ins(15;?)(q15;?)/46,idem,‐X, + 2,t(3;8),add(10),der(15). The finding of clonal structural aberrations suggests that fibrous dysplasia is a neoplastic lesion which develops as the result of somatic mutations.

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