On selecting sample sizes and discrete observation times for longitudinal mortality studies | Zendy

Hines R. J. O'Hara | Zendy; Hines W. G. S. | Zendy

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On selecting sample sizes and discrete observation times for longitudinal mortality studies

Author(s) -

Hines R. J. O'Hara,

Hines W. G. S.

Publication year - 1992

Publication title -

environmetrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.68

H-Index - 58

eISSN - 1099-095X

pISSN - 1180-4009

DOI - 10.1002/env.3170030302

Subject(s) - sample size determination , selection (genetic algorithm) , statistics , computer science , econometrics , sample (material) , scale (ratio) , mathematics , machine learning , geography , chemistry , cartography , chromatography

Guidelines are developed for the design and execution of grouped longitudinal mortality studies in toxicology so as to obtain useful information without excessive effort. Issues addressed include the selection of a suitable time scale and effects of group size and observation frequency on the chances of successful experimental runs and on statistical efficiency. Also discussed is the preliminary approximate information needed about mortality variability and times of first and final observations. An example illustrates the methods suggested.

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