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Revisiting the Addition of in‐situ Nucleophiles to Allenic Ketones: An Entry Towards Synthesis of Benzodioxins
Author(s) -
Sahoo Sushree Ranjan,
Sarkar Debayan
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202000076
Subject(s) - nucleophile , chemistry , regioselectivity , annulation , ring (chemistry) , scope (computer science) , substrate (aquarium) , combinatorial chemistry , organic chemistry , catalysis , computer science , programming language , oceanography , geology
The manuscript delineates a revisit towards regioselective addition of in situ generated negative nucleophiles to allenic ketones in the presence of a base. A wide variety of allenic ketones as well as nucleophiles are viable in this transformation. A direct ring annulation towards the challenging benzodioxin skeleton synthesis has been developed. Environmentally benign protocol and wide substrate scope are the notable features of this methodology.