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Ohmic Heating and Ionic Liquids in Combination for the Indium‐Promoted Synthesis of 1‐Halo Alkenyl Compounds: Applications to Pd‐Catalysed Cross‐Coupling Reactions
Author(s) -
Soengas Raquel G.,
Silva Vera L. M.,
Pinto Joana,
RodríguezSolla Humberto,
Silva Artur M. S.
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501162
Subject(s) - chemistry , indium , stille reaction , halogenation , reagent , reductive elimination , sonogashira coupling , palladium , ionic liquid , organic chemistry , catalysis , combinatorial chemistry
Abstract We have explored the combination of ohmic heating (ΩH) with ionic liquids for indium‐promoted reactions and report herein the indium‐promoted dehalogenation of gem ‐dibromo alkenes and the indium‐mediated reductive elimination of chlorohydrins for the synthesis of 1‐halo alkenyl derivatives. Heck, Stille, Suzuki, Kumada and Sonogashira couplings of the resulting 1‐halo‐1‐alkenes with appropriate reagents were carried out to give alkenes, dienes and enynes.