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Indium(III)‐Catalyzed Reductive Monoalkylation of Electron‐Rich Benzenes with Aliphatic Carboxylic Acids Leading to Arylalkane Derivatives
Author(s) -
Moriya Toshimitsu,
Takayama Kentaro,
Konakahara Takeo,
Ogiwara Yohei,
Sakai Norio
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500096
Subject(s) - chemistry , catalysis , indium , organic chemistry , carboxylic acid , combinatorial chemistry
Abstract Described herein is the reaction of electron‐rich aromatic compounds with aliphatic carboxylic acids treated with a catalytic amount (5 mol‐%) of InI 3 , 1,1,3,3‐tetramethyldisiloxane (TMDS), and molecular iodine. The reductive monoalkylation occurs smoothly to produce the corresponding arylalkane derivatives.