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Synthesis of Tetrasubstituted Olefins by Palladium‐Catalyzed Double Heck Cyclization of Bromoenynes
Author(s) -
Naveen Kanagaraj,
Muralidharan Doraiswamy,
Perumal Paramasivan Thirumalai
Publication year - 2014
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201301806
Subject(s) - chemistry , palladium , indene , catalysis , domino , heck reaction , stereoselectivity , palladium catalyst , organic chemistry , combinatorial chemistry
Abstract Palladium‐catalyzed regio‐ and stereoselective synthesis of tetrasubstituted olefins incorporating an indene scaffold was developed through 6‐ exo‐dig carbocyclization followed by Heck cyclization with anti β‐hydrogen elimination. The starting materials for the domino reaction were designed through an A 3 ‐coupling reaction.