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Synthesis of the N ‐Substituted Pyridin‐1(2 H )‐one Framework by Ligand‐Assisted Pd‐Catalyzed Reactions
Author(s) -
Zhou Kang,
Wen Ping,
Chen Wenlin,
Ma Chaowei,
Huang Guosheng
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201151
Subject(s) - chemistry , catalysis , ligand (biochemistry) , combinatorial chemistry , reaction mechanism , stereochemistry , medicinal chemistry , organic chemistry , receptor , biochemistry
An efficient Pd‐catalyzed method for the synthesis of N ‐substituted pyridin‐1(2 H )‐ones was developed. The corresponding derivatives, which can be found in numerous biologically active compounds, were obtained in good to excellent yields. A possible mechanism for this reaction is discussed.
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