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Synthesis of Functionalized Nitrogen Heterocycles by Radical Decarboxylation of β‐ and γ‐Amino Acids
Author(s) -
Boto Alicia,
Hernández Rosendo,
de León Yolanda,
Murguía José R.,
RodriguezAfonso Abigail
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400698
Subject(s) - decarboxylation , chemistry , antifungal , organic chemistry , nitrogen , amino acid , radical , combinatorial chemistry , catalysis , biochemistry , medicine , dermatology
Abstract Iodinated or oxygenated nitrogen heterocycles are obtained by radical decarboxylation of β‐ and γ‐amino acids. This mild, versatile reaction is applied to the synthesis of bioactive products, such as 4‐arylpiperidines, hydroxylated piperidines, and new antifungal agents.