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A Facile Synthesis of Optically Active β‐Amino‐β‐arylethylphosphonates by Mitsunobu Reaction
Author(s) -
Xu Chengfu,
Yuan Chengye
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400420
Subject(s) - optically active , chemistry , candida rugosa , kinetic resolution , mitsunobu reaction , combinatorial chemistry , aryl , lipase , catalysis , amino acid , enantioselective synthesis , organic chemistry , stereochemistry , enzyme , biochemistry , alkyl
Abstract We describe a convenient and simple synthesis of optically active β‐amino‐β‐arylethylphosphonates based on Mitsunobu reactions of chiral β‐aryl‐β‐hydroxyethylphosphonates, prepared in turn by Candida rugosa lipase catalyzed kinetic resolution of the corresponding racemates. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)