Premium
Microwave‐Assisted Solvent‐Free Synthesis of Hexahydrochromeno[4,3‐ b ]pyrroles
Author(s) -
Pospíšil Jiří,
Potáček Milan
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200300481
Subject(s) - chemistry , intramolecular force , steric effects , alkyl , solvent , green chemistry , stereochemistry , organic chemistry , reaction mechanism , catalysis
Abstract We report the microwave‐assisted solvent‐free synthesis of hexahydrochromeno[4,3‐ b ]pyrroles. Intramolecular 1,3‐dipolar cycloadditions proceed under these conditions within 15 min in 80% yields. Moreover, we have observed pronounced steric requirements of alkyl substituents toward the 1,3‐dipolar cycloadditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)