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Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands – Synthesis, Characterization, and Cytotoxicity
Author(s) -
Banfić Jelena,
Legin Anton A.,
Jakupec Michael A.,
Galanski Mathea Sophia,
Keppler Bernhard K.
Publication year - 2014
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.201301282
Subject(s) - chemistry , ferrocene , cytotoxicity , platinum , mtt assay , stereochemistry , in vitro , combinatorial chemistry , organic chemistry , biochemistry , electrode , electrochemistry , catalysis
Abstract Ferrocenyl compounds show interesting antiproliferative properties. Consequently, ferrocene bearing moieties were prepared and coupled for the first time to anticancer platinum(IV) complexes. The compounds, featuring either one or two axially coordinated ferrocene‐containing ligands, were fully characterized by ESI‐MS and multinuclear ( 1 H, 13 C, 15 N, and 195 Pt) one‐ and two‐dimensional NMR spectroscopy. Their cytotoxicity was investigated in three human cancer cell lines deriving from ovarian carcinoma (CH1), colon carcinoma (SW480), and non‐small‐cell lung carcinoma (A549) by means of the colorimetric MTT assay. Promising IC 50 values in the low micromolar range in CH1 and SW480 human cancer cells were found.