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NK1.1 + innate lymphoid cells in salivary glands inhibit establishment of tissue‐resident memory CD8 + T cells in mice
Author(s) -
Woyciechowski Sandra,
Weißert Kristoffer,
Ammann Sandra,
Aichele Peter,
Pircher Hanspeter
Publication year - 2020
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.202048741
Subject(s) - biology , lymphocytic choriomeningitis , cytotoxic t cell , innate lymphoid cell , interleukin 21 , cd8 , natural killer t cell , immunology , population , microbiology and biotechnology , innate immune system , immune system , genetics , demography , sociology , in vitro
Abstract NK1.1 + cells found in salivary glands (SG) represent a unique cell population of innate lymphoid cells (ILC) with characteristics of both conventional NK cells and ILC1. Here, we demonstrate that these NK1.1 + cells limit the accumulation and differentiation of virus‐specific tissue‐resident memory CD8 + T cells (T RM cells) in SG of mice infected with lymphocytic choriomeningitis virus (LCMV). The negative regulation of LCMV‐specific CD8 + T RM cells by NK1.1 + cells in SG is independent of NKG2D, NKp46, TRAIL, and perforin. Moreover, analysis of NKp46 iCre+ Eomes fl/fl mice revealed that Eomes‐dependent conventional NK cells are dispensable for negative regulation. Since the SG are prone to autoimmune reactions, regulation of T RM cells by tissue‐resident ILC may be particularly important to prevent immunopathology in this organ.