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The influence of phagocytic stimuli on the expression of HLA‐DR antigens; role of reactive oxygen intermediates
Author(s) -
Gruner Stefan,
Volk HansDieter,
And Peter Falck,
Baehr Rudiger Von
Publication year - 1986
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830160219
Subject(s) - zymosan , reactive oxygen species , peripheral blood mononuclear cell , antigen , biology , immunology , opsonin , superoxide dismutase , chronic granulomatous disease , microbiology and biotechnology , phagocytosis , oxidative stress , biochemistry , in vitro
Abstract Human peripheral blood mononuclear cells show after one day of culture with opsonized zymosan a decreased expression of HLA‐DR (but not HLA‐A, B, C) antigens, which can be prevented by the scavenger of reactive oxygen intermediates β‐carotene, or superoxide dismutase or indomethacin. Mononuclear cells of a patient with a heterozygous form of chronic granulomatous disease show no alterations in HLA‐DR antigen expression after culture with opsonized zymosan. Possible roles of reactive oxygen intermediates or prostaglandins in the modulation of HLA‐DR antigens are discussed.