Antibody diversity in amphibians: inheritance of isoelectric focusing antibody patterns in isogenic frogs
Author(s) -
Du Pasquier L.,
Wabl M. R.
Publication year - 1978
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830080611
Subject(s) - biology , isoelectric focusing , antibody , phosphorylcholine , xenopus , antigen , zoology , genetics , immunology , gene , biochemistry , enzyme
Abstract Anti‐sheep red cell, anti‐dinitrophenyl, anti‐phosphorylcholine antibody responses have been followed in isogenic frogs of the genus Xenopus . Isoelectric focusing antibody patterns show a high degree of overlap for all antigens studied, and a heterogeneity that is lower than in mammals for the same antigens. Inheritance of antibody isoelectric focusing spectrotypes was demonstrated for sheep red cells and dinitrophenyl in two clones of isogenic animals. Outbred frogs show a higher frequency of spectrotype sharing than outbred mammals. It is therefore suggested that antibody diversity is lower in frogs than in mammals.