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Active heterologous chain recombinants of monoclonal antibodies raised in related rabbits
Author(s) -
Braun D. G.,
Riesen W. F.,
Huser H.
Publication year - 1976
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830061113
Subject(s) - biology , heterologous , antibody , immunoglobulin light chain , monoclonal antibody , immunoglobulin heavy chain , homologous chromosome , virology , microbiology and biotechnology , genetics , gene
Abstract Heterologous chain recombinants of homogeneous anti‐streptococcal group A‐variant polysaccharide antibodies produced by pedigreed rabbits regain in certain pairs the same antigen‐binding capacity as the homologous pairs. In contrast, chain recombinants with antibodies from nonrelated rabbits are much less active. This data suggests random pairing of immunoglobulin heavy and light chains coded for in the germ line and subsequent selection.