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N‐terminal amino acid sequence of a human delta‐chain myeloma protein
Author(s) -
Milstein Celia P.,
Northrop F.
Publication year - 1976
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830060315
Subject(s) - biology , peptide sequence , myeloma protein , sequence (biology) , gene , chain (unit) , immunoglobulin light chain , amino acid , multiple myeloma , polypeptide chain , immunoglobulin heavy chain , terminal (telecommunication) , genetics , antibody , microbiology and biotechnology , biochemistry , immunology , physics , astronomy , telecommunications , computer science
Abstract The N‐terminal amino acid sequence (26 residues) of a δ‐chain of a human myeloma (Er I) is homologous with the prototype sequence of the human V H III subgroup. This indicates that the δ‐chain is using for its V region the same pool of V genes as the rest of the immunoglobulin classes. Implications of this finding are discussed.