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Hepatocellular carcinoma‐fibrolamellar variant: Cytopathology of an unusual case
Author(s) -
Kunz George,
Chung Jeffrey,
Ali Syed Z.
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10088
Subject(s) - medicine , cytopathology , hepatocellular carcinoma , malignancy , bile duct , fine needle aspiration , pathology , carcinoma , radiology , biopsy , gastroenterology , cytology
Abstract The fibrolamellar variant of hepatocellular carcinoma (FL‐HCC) is an uncommon visceral malignancy with a distinctly better prognosis. An accurate initial diagnosis, therefore, is essential for prognostic and therapeutic reasons. This case report describes the cytomorphology of an unusual case of FL‐HCC in a 13‐yr‐old boy who was found to have a hepatic mass with prominent intraluminal growth pattern seen predominantly in the right hepatic duct. A diagnosis of FL‐HCC was originally suspected on bile duct brushings obtained during endoscopic retrograde choleangiopancreaticogram (ERCP) and subsequently confirmed on fine‐needle aspiration (FNA) and surgical resection of the hepatic tumor. The cytomorphologic profile of FL‐HCC is distinctive in the right clinical setting, allowing an accurate preoperative identification of this malignancy on biliary brushing or FNA. Diagn. Cytopathol. 2002;26:257–261. © 2002 Wiley‐Liss, Inc.