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Monocyte CD169 expression in COVID ‐19 patients upon intensive care unit admission
Author(s) -
Ortillon Marine,
Coudereau Remy,
Cour Martin,
Rimmelé Thomas,
Godig Marine,
Gossez Morgane,
Yonis Hodane,
Argaud Laurent,
Lukaszewicz AnneClaire,
Venet Fabienne,
Monneret Guillaume
Publication year - 2021
Publication title -
cytometry part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 90
eISSN - 1552-4930
pISSN - 1552-4922
DOI - 10.1002/cyto.a.24315
Subject(s) - intensive care unit , triage , monocyte , sepsis , medicine , intensive care , covid-19 , emergency department , etiology , mechanical ventilation , flow cytometry , emergency medicine , immunology , intensive care medicine , disease , nursing , infectious disease (medical specialty)
Abstract During the second surge of COVID‐19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec‐1, one of the numerous IFN‐stimulated genes) upon admission to intensive care units of 45 patients with RT‐PCR‐confirmed SARS‐CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID‐19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID‐19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.