Premium
Switching to clozapine after one failed antipsychotic trial for schizophrenia
Publication year - 2018
Publication title -
the brown university child and adolescent psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7567
pISSN - 1527-8395
DOI - 10.1002/cpu.30340
Subject(s) - amisulpride , clozapine , olanzapine , schizophrenia (object oriented programming) , antipsychotic , medicine , atypical antipsychotic , typical antipsychotic , psychiatry , antipsychotic agent , psychology
Sequentially administering amisulpride and clozapine resulted in remission of early schizophrenia symptoms, with no improvement over that when patients switched to olanzapine, researchers found. Therefore, they recommended using clozapine after failure of a single antipsychotic, not after two failures, as is currently recommended.