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The respiratory effects of codeine and morphine in man
Author(s) -
Bellville J. Weldon,
Escarraga Lourdos Aguto,
Wallenstein Stanley L.,
Houde Raymond W.
Publication year - 1968
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt196894435
Subject(s) - codeine , morphine , potency , analgesic , medicine , pharmacology , anesthesia , respiratory system , intramuscular injection , chemistry , biochemistry , in vitro
A controlled study was carried out in human volunteers to compare the respiratory effects of codeine and morphine administered intramuscularly and codeine administered orally and intram1lScularly. Codeine intramuscularly was found to be 0.1 as potent as morphine. Oral codeine was 0.72 as potent as intramuscular codeine. These relative potency estimates are in close agreement to those published for analgesic relative potency. It is concluded that when intramuscular morphine and codeine or oral and intramuscular codeine are given in equianalgesic doses, similar degrees of respiratory depression are induced.