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Exercise Mimetics: Running Without a Road Map
Author(s) -
Li S,
Laher I
Publication year - 2017
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.533
Subject(s) - mitochondrial biogenesis , regulator , skeletal muscle , peroxisome proliferator activated receptor , peroxisome , oxidative phosphorylation , chemistry , biogenesis , receptor , pharmacology , mitochondrion , microbiology and biotechnology , endocrinology , medicine , biochemistry , biology , gene
Exercise mimetics are bioactive compounds that activate signaling pathways to simulate exercise‐like benefits. Physical exercise activates peroxisome proliferator‐activated receptor δ (PPAR δ), a master transcriptional regulator of skeletal muscle oxidative metabolism, and also stimulates AMP‐activated protein kinase, a regulator of skeletal muscle glucose uptake, fat oxidation, and mitochondrial biogenesis. Exercise mimetics have therapeutic potential by activating pathways that regulate metabolic endurance, but our knowledge of these compounds is based almost entirely on preclinical findings in rodents.