Back Cover: New Approaches in the Design and Development of Cannabinoid Receptor Ligands: Multifunctional and Bivalent Compounds (ChemMedChem 5/2015) | Zendy

Nimczick Martin | Zendy; Decker Michael | Zendy

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Back Cover: New Approaches in the Design and Development of Cannabinoid Receptor Ligands: Multifunctional and Bivalent Compounds (ChemMedChem 5/2015)

Author(s) -

Nimczick Martin,

Decker Michael

Publication year - 2015

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201590014

Subject(s) - bivalent (engine) , chemistry , cannabinoid receptor , stereochemistry , receptor , homology modeling , cannabinoid , docking (animal) , computational biology , cannabinoid receptor agonists , combinatorial chemistry , biochemistry , biology , antagonist , organic chemistry , medicine , enzyme , metal , nursing

The back cover picture shows a bivalent cannabinoid (CB) receptor 2 ligand and its parent ligand (structures created with PyMOL Molecular Graphics System v. 1.7.4.3, Schrödinger, LLC), which differ both in affinity and intrinsic activity. Due to their altered binding and pharmacology profiles, bivalent and multifunctional ligands are useful tools to explore CB receptors (CBRs) as therapeutic targets. For example, targeting of CBR (violet; homology model) and butyrylcholinesterase (red; PDB ID: 1P0I) by multifunctional CB ligands represents a promising therapeutic strategy for Alzheimer's disease. For further details, see the Minireview by Martin Nimczick and Michael Decker on p. 773 ff.

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