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cis ‐[Pt II (1 R ,2 R ‐DACH)(3‐acetoxy‐1,1‐cyclobutanedicarboxylato)], a Water‐Soluble, Oxalate‐Free and Stable Analogue of Oxaliplatin: Synthesis, Characterization, and Biological Evaluations
Author(s) -
Liu Weiping,
Ye Qingsong,
Jiang Jing,
Lou Liguang,
Xu Yongping,
Xie Chengying,
Xie Mingjin
Publication year - 2013
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201300249
Subject(s) - oxaliplatin , oxalate , aqueous solution , chemistry , derivative (finance) , solubility , computer science , combinatorial chemistry , medicinal chemistry , information retrieval , organic chemistry , medicine , colorectal cancer , business , cancer , finance
Strong, like ox! A new oxaliplatin derivative that features 3‐acetoxy‐1,1‐cyclobutanedicarboxylate as the leaving group has good aqueous solubility and stability. It exhibits higher antitumor activity and greater tolerability than oxaliplatin.