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Novel Rhein Analogues as Potential Anticancer Agents
Author(s) -
Yang Xiaochuan,
Sun Guojing,
Yang Chunhao,
Wang Binghe
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100384
Subject(s) - hela , potency , mtt assay , cancer cell lines , chemistry , stereochemistry , cell culture , combinatorial chemistry , cell , in vitro , biochemistry , biology , cancer cell , cancer , genetics
Two series of rhein analogues were synthesized with modification at the 3‐position. Their cytotoxicities were evaluated using an MTT assay. Among all the compounds synthesized, one compound showed the best potency, with an IC 50 value of 2.7 μ M against the HeLa cell line and 0.6 μ M against the MOLT4 cell line.
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