Copper‐Mediated Cyanation of Aryl C—H Bond with Removable Bidenate Auxiliary Using Acetonitrile as the Cyano Source | Zendy

Yu Zhengwei | Zendy; Zhang Saisai | Zendy; Shen Zengming | Zendy

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Copper‐Mediated Cyanation of Aryl C—H Bond with Removable Bidenate Auxiliary Using Acetonitrile as the Cyano Source

Author(s) -

Yu Zhengwei,

Zhang Saisai,

Shen Zengming

Publication year - 2018

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201800334

Subject(s) - cyanation , chemistry , acetonitrile , chemoselectivity , aryl , copper , salt (chemistry) , ammonium , medicinal chemistry , cyanide , combinatorial chemistry , organic chemistry , catalysis , alkyl

Copper‐mediated cyanation of aryl C—H bond with removable bidenate auxiliary as a directing group has been developed, in which green and cheap acetonitrile is used as the “CN” source. By switching the reaction conditions, the C—H cyanated products and N ‐Ar‐phthalimides can be provided in acceptable yields with high chemoselectivity, respectively. The use of quaternary ammonium salt is essential for cyanation reaction.

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