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A New Method for High‐Resolution NMR Spectra in Inhomogeneous Fields with Efficient Solvent Suppression
Author(s) -
Lin MeiJin,
Chen Xi,
Chen ZhiWei,
Chen Zhong
Publication year - 2007
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200790139
Subject(s) - chemistry , j coupling , pulse sequence , spectral line , nuclear magnetic resonance spectroscopy , chemical shift , nmr spectra database , intermolecular force , multiplet , coherence (philosophical gambling strategy) , magnetic field , coupling constant , nuclear magnetic resonance , homogeneity (statistics) , spectroscopy , nuclear magnetic resonance crystallography , resolution (logic) , solvent , two dimensional nuclear magnetic resonance spectroscopy , fluorine 19 nmr , molecule , physics , organic chemistry , stereochemistry , quantum mechanics , statistics , mathematics , artificial intelligence , computer science
Abstract High‐resolution nuclear magnetic resonance (NMR) is one of the most powerful tools for analyzing molecular structures and dynamics. Magnetic field homogeneity is required for conventional high‐resolution spectra. However, there are many chemical and/or biological circumstances where the spatial homogeneities of the magnetic fields are degraded. Intense solvent signal is another obstacle for obtaining high‐resolution spectra, especially in in vivo and in situ NMR spectroscopy. In this paper, a new pulse sequence based on intermolecular multiple quantum coherence (iMQC) was reported. This sequence can effectively remove the effect of magnetic field inhomogeneity and suppress the solvent signal. It can recover the spectral information such as chemical shifts, coupling constants, multiplet patterns, and relative peak areas in inhomogeneous fields. Theoretical analyses and experimental verifications are presented to demonstrate the feasibility of this method.