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Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids
Author(s) -
Jie Wu,
XiaoYu Xu,
KeLiang Liu
Publication year - 2003
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.20030210518
Subject(s) - chemistry , nucleic acid , peptide , peptide nucleic acid , monomer , chirality (physics) , nucleic acid analogue , amino acid , combinatorial chemistry , stereochemistry , nucleic acid methods , biochemistry , rna , organic chemistry , nucleic acid thermodynamics , polymer , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , gene , quark
N ‐Boc protected amino acids of analogues of peptide nucleic add (PNA.), which are a class of conformationally constrained building blocks based on 4‐aminoproline backbone with chirality at 2‐C and 4‐C, have been synthesized. Those monomers can be used for the construction of novel peptide nucleic acid analogues.
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