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A highly enantioselective synthesis of 5‐( l ‐menthyloxy )‐4‐substituted‐3‐chloro‐2(5 H )‐furanones
Author(s) -
Geng Zhe†,
Huang Bin,
Chen QingHua
Publication year - 1999
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19990170214
Subject(s) - chemistry , enantioselective synthesis , tandem , reaction conditions , stereochemistry , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , materials science , composite material
In this paper, stereocontrolled tandem Michael addition‐elimination reaction of the novel chiral source, 5‐( l ‐menthyloxy)‐3,4‐dichloro‐2(5 H )‐furanone, with various thiols and amines has been investigated. A series of new enantiomerically pure compounds, 5–( l ‐menthyloxy)‐4‐substituted‐3‐chloro‐2(5 H )‐furanones, were obtained in good yields with d. e . ⩾ 98% under mild conditions.
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