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Some reactions of fluorosulfonyldifluoroacetic acid with N ‐heterocyclic compounds
Author(s) -
Chen QingYun,
Yang GuoYing,
Wu ShengWen
Publication year - 1992
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.19920100410
Subject(s) - chemistry , organic chemistry , medicinal chemistry , combinatorial chemistry
Difluorocarbene generated from the decomposition of fluorosulfonyldifluoroacetic acid ( 2 ) reacted with various sodium salts of N ‐heterocyclic compounds( 1 ) giving the corresponding difluoromethylated products in acetonitrile at 10–40°C. Benzotriazole( 1a ), benzimidazole( 1b ) and imidazole ( 1c ) were converted into 1‐(difluoromethyl)benzotriazole( 3a ), 1‐(difluoromethyl)benzimidazole( 3b ) and 1‐(difluoromethyl)imidazole( 3c ) respectively. Indole( 1d ) reacted with 2 to give N ‐(fluorosulfonyldifluoroacetate)indole( 2d ) rather than the expected difluoromethylated derivatives.
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