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Synthesis of Single‐enantiomer Bioactive Molecules: A Brief Overview
Author(s) -
Rouf Abdul,
Taneja S.C.
Publication year - 2014
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.22268
Subject(s) - chemistry , enantiomer , chirality (physics) , stereoselectivity , combinatorial chemistry , biological activity , reagent , molecule , organic synthesis , stereochemistry , computational biology , organic chemistry , biochemistry , catalysis , in vitro , biology , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Chiral‐center enantiomers have been shown to differ significantly in biological activity , pharmacodynamics, pharmacokinetics and toxicity. New developments in the stereoselective organic synthesis have enriched the vast literature of synthetic methodologies applicable to access natural products as well as bioactive molecules. These compounds also include new drugs, drug candidates and reagents used to explore biological processes. The article reviews the synthesis of optically pure drugs, biologically active intermediates and amino alcohols by using different methods. Chirality 26:63–78, 2014 . © 2013 Wiley Periodicals, Inc.
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