Allylation and propargylation of chiral cyanopropanoates: An efficient route to long chain α‐substituted α‐methyl α‐amino acids | Zendy

Cativiela Carlos | Zendy; DíazDeVillegas María D. | Zendy; Gálvez José A. | Zendy; Ronco Eva | Zendy

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Allylation and propargylation of chiral cyanopropanoates: An efficient route to long chain α‐substituted α‐methyl α‐amino acids

Author(s) -

Cativiela Carlos,

DíazDeVillegas María D.,

Gálvez José A.,

Ronco Eva

Publication year - 2003

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.10312

Subject(s) - chemistry , chirality (physics) , amino acid , side chain , stereochemistry , alpha (finance) , combinatorial chemistry , organic chemistry , chiral symmetry , biochemistry , physics , quantum mechanics , nambu–jona lasinio model , quark , polymer , medicine , construct validity , nursing , patient satisfaction

α‐Methyllysine and 2‐amino‐2‐methylundecanoic acid, two α,α‐disubstituted unnatural glycines, were synthesized using highly diastereoselective allylation or propargylation of chiral (1 S ,2 R ,4 R )‐10‐dicyclohexylsulfamoylisobornyl 2‐cyanopropanoate as the key step to introduce the long side chain. Chirality 16:106–111, 2004 . © 2004 Wiley‐Liss, Inc.

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